Fator de crescimento fibroblástico 7

FGF7
Identificadores
Nomes alternativos	FGF7
IDs externos	OMIM: 148180 HomoloGene: 7316 GeneCards: FGF7
Ontologia genética
Função molecular	• heparin binding; • fibroblast growth factor receptor binding; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • chemoattractant activity; • growth factor activity; • 1-phosphatidylinositol-3-kinase activity; • protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Componente celular	• complexo de Golgi; • extracellular region;
Processo biológico	• actin cytoskeleton reorganization; • mesenchymal cell proliferation; • positive regulation of keratinocyte proliferation; • positive regulation of epithelial cell proliferation involved in lung morphogenesis; • secretion by lung epithelial cell involved in lung growth; • positive regulation of epithelial cell proliferation; • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; • MAPK cascade; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • fibroblast growth factor receptor signaling pathway; • positive regulation of keratinocyte migration; • protein localization to cell surface; • response to wounding; • positive regulation of cell population proliferation; • epidermis development; • positive regulation of peptidyl-tyrosine phosphorylation; • hair follicle morphogenesis; • positive chemotaxis; • positive regulation of cell division; • GO:0072468 transdução de sinal; • branching involved in salivary gland morphogenesis; • phosphatidylinositol phosphate biosynthetic process; • peptidyl-tyrosine phosphorylation; • phosphatidylinositol-3-phosphate biosynthetic process; • regulation of signaling receptor activity; • positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	2252
	n/a
	ENSG00000140285
	n/a
	P21781
	n/a
	NM_002009
	n/a
	NP_002000
	n/a
	Wikidata
Ver/Editar Humano

Fator de crescimento de queratinócitos é uma proteína que em humanos é codificada pelo gene FGF7.^[2]^[3]^[4]

Função

A proteína codificada por este gene é um membro da família do fator de crescimento de fibroblastos (FGF). Os membros da família FGF possuem amplas atividades mitogênicas e de sobrevivência celular, e estão envolvidos numa variedade de processos biológicos, incluindo desenvolvimento embrionário, crescimento celular, morfogênese, reparo tecidual, crescimento de tumores e invasão. Esta proteína é um potente fator de crescimento específico para células epiteliais, cuja atividade mitogênica é exibida predominantemente em queratinócitos, mas não em fibroblastos e células endoteliais. Estudos de homólogos deste gene em camundongos e ratos implicaram papéis na morfogênese do epitélio, reepitelização de feridas, desenvolvimento capilar e organogênese pulmonar inicial.^[4]

Interações

Foi demonstrado que o FGF7 interage com o perlecan [en].^[5]

Referências

↑ «Human PubMed Reference:»
↑ Mattei MG, deLapeyrière O, Bresnick J, Dickson C, Birnbaum D, Mason I (março de 1995). «Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively». Mammalian Genome. 6 (3): 196–7. PMID 7749227. doi:10.1007/BF00293012
↑ Kelley MJ, Pech M, Seuanez HN, Rubin JS, O'Brien SJ, Aaronson SA (outubro de 1992). «Emergence of the keratinocyte growth factor multigene family during the great ape radiation». Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 9287–91. Bibcode:1992PNAS...89.9287K. PMC 50111. PMID 1409637. doi:10.1073/pnas.89.19.9287
↑ ^a ^b «Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)»
↑ Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (março de 2000). «The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7». The Journal of Biological Chemistry. 275 (10): 7095–100. PMID 10702276. doi:10.1074/jbc.275.10.7095

Leitura adicional

Beer HD, Gassmann MG, Munz B, Steiling H, Engelhardt F, Bleuel K, Werner S (dezembro de 2000). «Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair». The Journal of Investigative Dermatology. Symposium Proceedings. 5 (1): 34–9. PMID 11147673. doi:10.1046/j.1087-0024.2000.00009.x
Ware LB, Matthay MA (maio de 2002). «Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair». American Journal of Physiology. Lung Cellular and Molecular Physiology. 282 (5): L924–40. PMID 11943656. doi:10.1152/ajplung.00439.2001
Finch PW, Rubin JS (2004). Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Col: Advances in Cancer Research. 91. [S.l.: s.n.] pp. 69–136. ISBN 978-0-12-006691-9. PMID 15327889. doi:10.1016/S0065-230X(04)91003-2
Ishibashi T, Bottaro DP, Chan A, Miki T, Aaronson SA (dezembro de 1992). «Expression cloning of a human dual-specificity phosphatase». Proceedings of the National Academy of Sciences of the United States of America. 89 (24): 12170–4. Bibcode:1992PNAS...8912170I. PMC 50720. PMID 1281549. doi:10.1073/pnas.89.24.12170
Aaronson SA, Bottaro DP, Miki T, Ron D, Finch PW, Fleming TP, Ahn J, Taylor WG, Rubin JS (1992). «Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity». Annals of the New York Academy of Sciences. 638: 62–77. PMID 1664700. doi:10.1111/j.1749-6632.1991.tb49018.x
Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA (agosto de 1989). «Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth». Science. 245 (4919): 752–5. Bibcode:1989Sci...245..752F. PMID 2475908. doi:10.1126/science.2475908
Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA (fevereiro de 1989). «Purification and characterization of a newly identified growth factor specific for epithelial cells». Proceedings of the National Academy of Sciences of the United States of America. 86 (3): 802–6. Bibcode:1989PNAS...86..802R. PMC 286565. PMID 2915979. doi:10.1073/pnas.86.3.802
Ron D, Reich R, Chedid M, Lengel C, Cohen OE, Chan AM, Neufeld G, Miki T, Tronick SR (março de 1993). «Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor». The Journal of Biological Chemistry. 268 (8): 5388–94. PMID 7680645. doi:10.1016/S0021-9258(18)53334-2
Yan G, Fukabori Y, McBride G, Nikolaropolous S, McKeehan WL (agosto de 1993). «Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy». Molecular and Cellular Biology. 13 (8): 4513–22. PMC 360063. PMID 7687739. doi:10.1128/MCB.13.8.4513
Werner S, Smola H, Liao X, Longaker MT, Krieg T, Hofschneider PH, Williams LT (novembro de 1994). «The function of KGF in morphogenesis of epithelium and reepithelialization of wounds». Science. 266 (5186): 819–22. Bibcode:1994Sci...266..819W. PMID 7973639. doi:10.1126/science.7973639
Wilson SE, Walker JW, Chwang EL, He YG (julho de 1993). «Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea». Investigative Ophthalmology & Visual Science. 34 (8): 2544–61. PMID 8392040
Guo L, Degenstein L, Fuchs E (janeiro de 1996). «Keratinocyte growth factor is required for hair development but not for wound healing». Genes & Development. 10 (2): 165–75. PMID 8566750. doi:10.1101/gad.10.2.165
Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M (junho de 1996). «Receptor specificity of the fibroblast growth factor family». The Journal of Biological Chemistry. 271 (25): 15292–7. PMID 8663044. doi:10.1074/jbc.271.25.15292
Post M, Souza P, Liu J, Tseu I, Wang J, Kuliszewski M, Tanswell AK (outubro de 1996). «Keratinocyte growth factor and its receptor are involved in regulating early lung branching». Development. 122 (10): 3107–15. PMID 8898224. doi:10.1242/dev.122.10.3107
Zimonjic DB, Kelley MJ, Rubin JS, Aaronson SA, Popescu NC (outubro de 1997). «Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans». Proceedings of the National Academy of Sciences of the United States of America. 94 (21): 11461–5. Bibcode:1997PNAS...9411461Z. PMC 23506. PMID 9326632. doi:10.1073/pnas.94.21.11461
Winkles JA, Alberts GF, Chedid M, Taylor WG, DeMartino S, Rubin JS (dezembro de 1997). «Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries». Journal of Cellular Physiology. 173 (3): 380–6. PMID 9369951. doi:10.1002/(SICI)1097-4652(199712)173:3<380::AID-JCP10>3.0.CO;2-G
Ishibashi T, Tanaka T, Nibu K, Ishimoto S, Kaga K (outubro de 1998). «Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps». The Annals of Otology, Rhinology, and Laryngology. 107 (10 Pt 1): 885–90. PMID 9794620. doi:10.1177/000348949810701013
Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (março de 2000). «The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7». The Journal of Biological Chemistry. 275 (10): 7095–100. PMID 10702276. doi:10.1074/jbc.275.10.7095

[1] «Human PubMed Reference:»

[pmid7749227-2] Mattei MG, deLapeyrière O, Bresnick J, Dickson C, Birnbaum D, Mason I (março de 1995). «Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively». Mammalian Genome. 6 (3): 196–7. PMID 7749227. doi:10.1007/BF00293012

[pmid1409637-3] Kelley MJ, Pech M, Seuanez HN, Rubin JS, O'Brien SJ, Aaronson SA (outubro de 1992). «Emergence of the keratinocyte growth factor multigene family during the great ape radiation». Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 9287–91. Bibcode:1992PNAS...89.9287K. PMC 50111. PMID 1409637. doi:10.1073/pnas.89.19.9287

[entrez-4] «Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)»

[pmid10702276-5] Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (março de 2000). «The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7». The Journal of Biological Chemistry. 275 (10): 7095–100. PMID 10702276. doi:10.1074/jbc.275.10.7095

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